Inventi Rapid: Pharm Analysis & Quality Assurance

Inventi:prpaqa/81243/25

Novel Analytical Design of Molnupiravir

An analytical design was framed for the establishment of molnupiravir in bulk and pharmaceutical dosage form. The high performance thin layer chromatographic technique was attempted; the stationary phase used for this investigation is silica gel 60 F254 HPTLC plate. The ethyl acetate: methanol: Toluene in the volume ratio of 5.0:3:0:2.0 was the mobile phase. The Rf value was optimized as 0.42. The determination was performed at 235 nm. The validations were stepped for the various parameters such as linearity, accuracy, precision and specificity. The statistical analysis has been demonstrated for the confirmation and assurance of accuracy and reproducibility. The linearity range was 100 to 500 ng/spot. The limit of detection and limit of quantitation for molnupiravir were 30 and 90 ng/spot respectively. The novel design can be successfully applied for the analytical establishment of molnupiravir in the capsule dosage form....