Current Issue : October-December Volume : 2024 Issue Number : 4 Articles : 1 Articles
Aim of this research was development and implementation of a simple, precise and accurate zero order spectroscopic method for the estimation of levetiracetam in bulk and tablet dosage form. The drug indicates the maximum absorption (λmax) at 206 nm in 0.5 N HCl solutions (pH about 3.3) and AUC in the absorption spectrum is measured in the wavelength range from 204 to 208 nm at a concentration range of 5-30 µg/ml according to Beer’s law. Linearity analysis showed an R2 value of 0.998. The %Recovery was found to be 99.99 to 100.92 %. The LOD and LOQ were found to be 0.0110 and 0.33 µg/ml. The %RSD was found less than 2. The method has been validated according to linearity, precision, accuracy, robustness, ruggedness, LOD and LOQ according to ICH guidelines. This method obeys the Beer’s law and met all the required specifications within the limit. FTIR data interpretation also gives information about purity and quality of sample and it also meets the required specifications....
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