Current Issue : July-September Volume : 2026 Issue Number : 3 Articles : 2 Articles
This research presents the systematic development and validation of a Gas Chromatography with Flame Ionization Detection [GC-FID] method for the quantitative evaluation and purity assessment of 4-Hydroxy-2-butanone [4H2B] and 1,3 Butylene Glycol [1,3 BG]. Aligned with the International Council for Harmonisation [ICH] Q2 [R1] guidelines, the method was rigorously evaluated for key performance indicators, including specificity, linearity, precision, accuracy and robustness. The experimental results demonstrate exceptional baseline separation, minimal peak distortion and robust reproducibility, rendering this method highly suitable for routine impurity profiling and quality control assessments of biobased value-added chemicals....
The present work aims to establish a simple, precise and rapid spectrophotometric method for quantifying telmisartan in active pharmaceutical ingredients. This work was carried out to estimate telmisartan in bulk by utilizing an area under curve (AUC) method using uv-visible spectrophotometry. For this purpose, the wavelength range between 200-400 nm was selected. Ethanol was used as a solvent throughout the work. Linearity was obtained in the concentration range of 2 to 10 g/ml (r2 =0.998) for the method. The developed method was found to be simple, highly sensitive and can be used for routine quality control analysis for spectrophotometric estimation of active pharmaceutical ingredients....
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